Hyaluronic Acid-Curcumin Complex Triggers Apoptotic Pathway in Breast Cancer Cells via CD44 Receptors

نویسندگان

چکیده

Objective: Curcumin (CUR) was modified with hyaluronic acid (HA) to increase its water solubility and bioavailability. Our aim the uptake of CUR into cells that express CD44 receptors compare cellular effects in two different human breast carcinoma cells, MCF-7 MDA-MB-231. 
 Methods: Hyaluronic acid-curcumin complex (HA-CUR) synthesized characterized. MDA-MB-231 were grown under appropriate conditions effect HA-CUR on cell viability determined. Apoptosis levels after treatment also measured. receptor both compared then apoptosis measured saturation CD 44 HA. In expression caspase-9 PARP analyzed confirm apoptosis. Results: percentage level group slightly lower than group. no statistically significant difference found control group, but higher cells. Blocking reversed apoptotic Both had Conclusion: Conjugation HA, which is specific for aids, entry target making it a powerful agent targeted cancer therapy.

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ژورنال

عنوان ژورنال: Clinical and Experimental Health Sciences

سال: 2023

ISSN: ['2459-1459']

DOI: https://doi.org/10.33808/clinexphealthsci.1185564